Monday, February 20, 2012

New Life, From an Arctic Flower That Died 32,000 Years Ago - NYTimes.com

Dead for 32,000 Years, an Arctic Plant Is Revived

Living plants have been generated from the fruit of a little arctic flower, the narrow-leafed campion, that died 32,000 years ago, a team of Russian scientists reports. The fruit was stored by an arctic ground squirrel in its burrow on the tundra of northeastern Siberia and lay permanently frozen until excavated by scientists a few years ago.

This would be the oldest plant by far that has ever been grown from ancient tissue. The present record is held by a date palm grown from a seed some 2,000 years old that was recovered from the ancient fortress of Masada in Israel.

Seeds and certain cells can last a long term under the right conditions, but many claims of extreme longevity have failed on closer examination, and biologists are likely to greet this claim, too, with reserve until it can be independently confirmed. Tales of wheat grown from seeds in the tombs of the pharaohs have long been discredited. Lupines were germinated from seeds in a 10,000-year-old lemming burrow found by a gold miner in the Yukon. But the seeds, later dated by the radiocarbon method, turned out to be modern contaminants.

Despite this unpromising background, the new claim is supported by a firm radiocarbon date. A similar avenue of inquiry into the deep past, the field of ancient DNA, was at first discredited after claims of retrieving dinosaur DNA proved erroneous, but with improved methods has produced spectacular results like the reconstitution of the Neanderthal genome.

The new report is by a team led by Svetlana Yashina and David Gilichinsky of the Russian Academy of Sciences research center at Pushchino, near Moscow, and appears in Tuesday’s issue of The Proceedings of the National Academy of Sciences of the United States of America.

“This is an amazing breakthrough,” said Grant Zazula of the Yukon Paleontology Program at Whitehorse in Yukon Territory, Canada. “I have no doubt in my mind that this is a legitimate claim.” It was Dr. Zazula who showed that the apparently ancient lupine seeds found by the Yukon gold miner were in fact modern.

But the Russians’ extraordinary report is likely to provoke calls for more proof. “It’s beyond the bounds of what we’d expect,” said Alastair Murdoch, an expert on seed viability at the University of Reading in England. When poppy seeds are kept at minus 7 degrees Celsius, the temperature the Russians reported for the campions, after only 160 years just 2 percent of the seeds will be able to germinate, Dr. Murdoch noted.

The Russian researchers excavated ancient squirrel burrows exposed on the bank of the lower Kolyma River, an area thronged with mammoth and woolly rhinoceroses during the last ice age. Soon after being dug, the burrows were sealed with windblown earth, buried under 125 feet of sediment and permanently frozen at minus 7 degrees Celsius.

Some of the storage chambers in the burrows contain more than 600,000 seeds and fruits. Many are from a species that most closely resembles a plant found today, the narrow-leafed campion (Silene stenophylla).

Working with a burrow from the site called Duvanny Yar, the Russian researchers tried to germinate the campion seeds, but failed. They then took cells from the placenta, the organ in the fruit that produces the seeds. They thawed out the cells and grew them in culture dishes into whole plants.

Many plants can be propagated from a single adult cell, and this cloning procedure worked with three of the placentas, the Russian researchers report. They grew 36 ancient plants, which appeared identical to the present day narrow-leafed campion until they flowered, when they produced narrower and more splayed-out petals. Seeds from the ancient plants germinated with 100 percent success, compared with 90 percent for seeds from living campions.

The Russian team says it obtained a radiocarbon date of 31,800 years from seeds attached to the same placenta from which the living plants were propagated.

The researchers suggest that special circumstances may have contributed to the remarkable longevity of the campion plant cells. Squirrels construct their larders next to permafrost to keep seeds cool during the arctic summers, so the fruits would have been chilled from the start. The fruit’s placenta contains high levels of sucrose and phenols, which are good antifreeze agents.

The Russians measured the ground radioactivity at the site, which can damage DNA, and say the amount of gamma radiation the campion fruit accumulated over 30,000 years is not much higher than that reported for a 1,300-year-old sacred lotus seed, from which a plant was successfully germinated.

The Russian article was edited by Buford Price of the University of California, Berkeley. Dr. Price, a physicist, chose two reviewers to help him. But neither he nor they are plant biologists. “I know nothing about plants,” he said. Ann Griswold, a spokeswoman for the National Academy of Sciences, said the paper had been seen by an editorial board member who is a plant biologist.

Tragedy has now struck the Russian team. Dr. Gilichinksy, its leader, was hospitalized with an asthma attack and unable to respond to questions, his daughter Yana said on Friday. On Saturday, Dr. Price reported that Dr. Gilichinsky had died of a heart attack.

Eske Willerslev, an expert on ancient DNA at the University of Copenhagen, said the finding was “plausible in principle,” given the conditions in permafrost. But the claim depends on the radiocarbon date being correct: “It’s all resting on that — if there’s something wrong there it can all fall part.”

If the ancient campions are the ancestors of the living plants, this family relationship should be evident in their DNA. Dr. Willerslev said that the Russian researchers should analyze the DNA of their specimens and prove that this is the case. However, this is not easy to do with plants whose genetics are not well studied, Dr. Willerslev said.

If the claim is true, then scientists should be able to study evolution in real time by comparing the ancient and living campions. Possibly other ancient species can be resurrected from the permafrost, including plants that have long been extinct.

Posted via email from Tony Burkhart

“That Time We Beat the Americans” by Stephen Marche | The Walrus | March 2012

That Time We Beat the Americans

Illustration by Lauchie ReidFort York, Toronto
Canada exists
for no natural reason
Let’s begin with an obvious fact no one will admit: Canadians and Americans are more or less the same people. A Torontonian in New York does not stick out, while a Kentuckian well might. Neither does a resident of Medicine Hat, Alberta, feel out of place in Butte, Montana, though a Vancouverite definitely would. Which is not to say that no significant differences exist between Canadians and Americans — just that our shared national border, unlike those of Europe, was not shaped by linguistic and ethnic variations. The War of 1812 made all the difference here. A complicated and unpleasant struggle, mostly forgotten, sundered our two countries. And that struggle is now 200 years old, which makes this as good a time as any to start remembering.

Canada exists because of
the War of 1812
Military historians generally describe the War of 1812 as a stalemate. After two and a half years of fighting, not much changed between the United States and England, nor between the United States and Canada. But the war — as much as the more decisive battle of the Plains of Abraham, the American Revolution, and the Civil War — foretold North America’s political shape, its current reality. For the US, the war confirmed its status as a sovereign state and tested the limits of manifest destiny. On this side of the border, the matter is much simpler: if we hadn’t won the War of 1812, we wouldn’t be Canadian.

Canada exists because of
taxes (and tax breaks)
In a continental irony, after the revolution the new American government had to raise taxes far higher than British authorities had ever dreamt of doing, to finance the overthrow of Westminster rule. Across the border, the British suddenly realized colonists could easily grow alienated. So they lowered taxes and offered prospective settlers of Upper Canada 200 acres of free land. Loyalists and late Loyalists, followed by tax exiles and land speculators from the newly united States, quickly populated what would become the province of Ontario. Upper Canada’s settler population ballooned, from 6,000 in 1785 to 14,000 in 1791, with men and women looking for opportunities and willing to wink at their US citizenship — just as British officials willingly welcomed them back from their flirtation with liberty, without too many questions.

Major General Sir Isaac BrockIllustration by Lauchie ReidHe was born on October 6, 1769, to an upper-class family from the Channel Island of Guernsey. Although he purchased each of his ranks, except for his captaincy, his tactical brilliance and empathy drew praise from his superior officers. Brock was assigned to Canada in 1802, but he disliked the colony. He regarded it as a backwater and would have rather been fighting, and dining, in Europe.

He played a primarily administrative role in Montreal, until the governor general, Sir George Prevost, appointed him Upper Canada’s military leader and acting lieutenant-governor, in 1811. Brock’s defining moment, the battle of Queenston Heights, took place on October 13, 1812. With his captains busy commanding the grenadiers, he led the charge against American forces embedded atop the Niagara Escarpment. The general was shot in the chest at close range, and died on a battlefield just north of Niagara Falls.

But Brock lives on across the country — most of which wasn’t even part of Canada when he was alive. Consider the countless roads, towns, and institutions that bear his name: Vancouver has General Brock Elementary School; Saskatchewan has the village of Brock; Newfoundland has Brock’s Head Path. In Ottawa, steps from Parliament Hill, a bust of him can be found at the Valiants Memorial, which honours fourteen of Canada’s war heroes, three of them from the War of 1812. There, a bronze inscription quotes Virgil: “No day will ever erase you from the memory of time.”

— Barry Chong

So in the days leading up to the war, it was optimistic but not preposterous for Representative John A. Harper of New Hampshire to predict that Canadians would greet American soldiers as liberators: “They must sigh for an affiliation with the great American family — they must at least in their hearts hail that day, which separates them from a foreign monarch, and unites them by holy and unchangeable bonds, with a nation destined to rule a continent.” They would not, after all, be invaded by a foreign people. Canadians would be brought back into the fold of American Revolutionary ideals.

What occurred two centuries ago was more or less a family feud. The Pulitzer Prize–winning historian Alan Taylor titled his 2010 survey of the conflict The Civil War of 1812 — a phrase that captures the profound connection between the combatants, and the unstable relationship between the Empire and the Republic. “Brother fought brother in a borderland of mixed peoples,” he writes. Those on both sides instantly recognized, and noted, the unique horror of firing on people so like themselves.

Canada exists
because of Hubris
The reasons the United States invaded Canada were, and remain, contentious and unclear. Officially, residues of the revolution — unresolved issues of maritime law, military conscription, and possession of the Ohio Country — led to the declaration of war on June 18, 1812. But the unofficial reasons — the prize and the odds of success — were grubby, petty. “United States,” then as now, was something of a misnomer, and the war emerged out of squabbling between the majority Jeffersonian Republicans, who hungered for expansion, and the minority Federalists, who benefited from close economic ties with Britain. By declaring war, the Republicans intended to make the Federalists look anti-patriotic and undemocratic. Both parties, however, believed the conquest of Upper and Lower Canada would be a cakewalk. At sea, the Royal Navy, though sixty times the size of the fledging US Navy, was distracted by Napoleon’s ships; on land, nearly eight million Americans would square off against just 300,000 Canadians. In August 1812, former president Thomas Jefferson declared, “The acquisition of Canada, this year, as far as the neighborhood of Quebec, will be a mere matter of marching.”

Canada exists because of
a series of lucky breaks
The comedy of errors began immediately. Even though the United States declared war, which should have given its soldiers the advantage of surprise, a messenger carried the news to Canadian military outposts on the Niagara River before it reached the New York side. British soldiers quickly detained several important — and unsuspecting — American personages on our side of the river. The initial blunder served as a telling prequel to subsequent disasters.

Illustration by Lauchie ReidBattlefield Park, Stoney Creek, Ontario
Canada exists because of
blundering Americans
The grand view of history has traditionally offered two paths for the interpretation of events. The first imagines social trends rising up from below to sweep humanity along in their irrepressible, all-powerful waves. The other dreams of iconic figures who shape history through their own vision and will. In the case of the United States during the War of 1812, we find neither. Instead, a third way emerges: history dominated by stupidity and impulse. From the revolution to the present moment, hardly a single generation of Americans has passed without giving rise to a bona fide military genius. The Civil War alone produced half a dozen. To Canada’s good fortune, the post-revolution US Army was stacked with bunglers and officers past their prime. It might have taken Canada easily, if not for the miraculously systemic idiocy among the top brass.

Canada exists because of
William Hull
Every Canadian city should build a statue to Brigadier General William Hull, because it is largely thanks to the American officer’s poor planning and cowardice that our provinces and territories do not number among a Star-Spangled constellation. Taylor describes Hull as “tall, strong, and courtly, he looked the part of a war hero, but he lacked substance, alternating an imperious manner with chronic indecision.” He drank. He bragged. His subordinates despised him. President James Madison, at Hull’s urging, made the terrible decision to divide the already weak army into three and attack Upper Canada from Detroit. If the United States had decided to strike straight at Montreal — a strategy confused by backroom dealings with a political heavyweight from Ogdensburg, New York, who didn’t want his land trampled on — it might well have been “a mere matter of marching,” as Jefferson predicted.

TecumsehIllustration by Lauchie ReidHe belongs to a tradition of misappropriated heroes, whereby one-time enemies are whitewashed as icons of a popular history. Canadians have named streets and schools after him, and the Friends of the Tecumseh Monument are now raising $5 million to honor his legacy in Southwestern Ontario. At the US Naval Academy in Annapolis, Maryland, midshipmen rally around a bronze likeness, in the aptly named Tecumseh Court, which they cover in war paint for Commissioning Week, during exams, and before they face football rivals.

In life, Tecumseh fought for the survival and continued sovereignty of the Shawnee people. Born in the Ohio Country in 1768 and killed on October 5, 1813, near Moraviantown, Upper Canada, he campaigned for a confederacy of Indigenous nations. He urged Aboriginal leaders, from the Great Lakes to Georgia, to affirm pan-tribal ownership of the land — to reject settler-imposed boundaries.

During the War of 1812, he allied with the British to fight a common enemy. As Isaac Brock declared, “A more sagacious or more gallant Warrior does not I believe exist. He was the admiration of everyone who conversed with him.” Yet British actions in the battle of the Thames were not as gallant. Despite plans to fight side by side, Major General Henry Proctor retreated, leaving Tecumseh’s vastly outnumbered men to face the Americans alone. Tecumseh’s Confederacy was overwhelmed; its leader died and, along with him, the last, best chance for Aboriginal self-governance.

— Bronwen Jervis

But Canadians can thank William Hull for much more than his dreadful advice to the president. In person, he was a military buffoon and an accidental nation maker. On July 5, 1812, he arrived in Detroit with orders to take the small town of Amherstburg, just across the river. He found the town well fortified, so he sent his men instead to the undefended settlement of Sandwich, whose inhabitants immediately fled. At Sandwich (now Windsor, Ontario), he made one of the most important pronouncements in Canadian history, declaring, “No white man found fighting by the side of an Indian will be taken prisoner. Instant destruction will be his lot.” Since every Canadian militiaman and British regular served alongside Aboriginal allies, the edict effectively promised death to any farmer or shopkeeper who resisted invasion. Then Hull allowed his soldiers to plunder homes, shops, and farms, and he continued to avoid a battle at Amherstburg, even though his men outnumbered the British and Canadian troops by two to one. His cowardice proved as sizable as his malice.

Spurred on by American incompetence, the residents of Upper Canada chose to fight, where before they had been rather ambivalent and resigned to retreat. Hull squandered his military dominance and achieved the worst possible outcome. He was unnecessarily brutal, cowardly and, worst of all, totally ineffective. The major outcome of his campaign was that he left behind settlers — who may or may not have been Loyalists and late Loyalists before — who were now self-conscious possessors of a territory and a recognizable identity.

William Hull ineffectually assaulted a disparate group of people. He left behind a cohesive, distinct Canadian community.

Canada exists because of
Aboriginal allies
Tecumseh was a Shawnee leader and one of the great military minds of all time. Outside the walls of Fort Detroit, he marched his men around and around, out of sight and back again, making his force appear five times larger than it was. The sleight of hand worked. Terrified, Hull liquored up and neglected his troops. The soldiers and militiamen under his command, both humiliated and scared, plotted mutiny. Major General Sir Isaac Brock, military commander and acting Lieutenant-Governor of Upper Canada, had fewer men, and Hull held the fort. But all Brock had to do was threaten further use of Tecumseh’s force — the terror of all American soldiers. Hull’s men deserted, and he surrendered without a fight. Brock and Tecumseh were so disgusted by their opponent that they didn’t even grant him the customary honours of war.

Mohawks, Oneidas, Onondagas, Tuscaroras, Cayugas, Senecas, and other First Nations fought alongside British detachments and Canadian militias throughout the war, and they played pivotal roles at the battles of Queenston Heights, the Thames, and Stoney Creek, all up and down the Niagara Peninsula. Yet we rarely recognize this fact.

Sent from my iPhone

Posted via email from Tony Burkhart

How Companies Learn Your Secrets - NYTimes.com

How Companies Learn Your Secrets

Andrew Pole had just started working as a statistician for Target in 2002, when two colleagues from the marketing department stopped by his desk to ask an odd question: “If we wanted to figure out if a customer is pregnant, even if she didn’t want us to know, can you do that? ”

Pole has a master’s degree in statistics and another in economics, and has been obsessed with the intersection of data and human behavior most of his life. His parents were teachers in North Dakota, and while other kids were going to 4-H, Pole was doing algebra and writing computer programs. “The stereotype of a math nerd is true,” he told me when I spoke with him last year. “I kind of like going out and evangelizing analytics.”

As the marketers explained to Pole — and as Pole later explained to me, back when we were still speaking and before Target told him to stop — new parents are a retailer’s holy grail. Most shoppers don’t buy everything they need at one store. Instead, they buy groceries at the grocery store and toys at the toy store, and they visit Target only when they need certain items they associate with Target — cleaning supplies, say, or new socks or a six-month supply of toilet paper. But Target sells everything from milk to stuffed animals to lawn furniture to electronics, so one of the company’s primary goals is convincing customers that the only store they need is Target. But it’s a tough message to get across, even with the most ingenious ad campaigns, because once consumers’ shopping habits are ingrained, it’s incredibly difficult to change them.

There are, however, some brief periods in a person’s life when old routines fall apart and buying habits are suddenly in flux. One of those moments — the moment, really — is right around the birth of a child, when parents are exhausted and overwhelmed and their shopping patterns and brand loyalties are up for grabs. But as Target’s marketers explained to Pole, timing is everything. Because birth records are usually public, the moment a couple have a new baby, they are almost instantaneously barraged with offers and incentives and advertisements from all sorts of companies. Which means that the key is to reach them earlier, before any other retailers know a baby is on the way. Specifically, the marketers said they wanted to send specially designed ads to women in their second trimester, which is when most expectant mothers begin buying all sorts of new things, like prenatal vitamins and maternity clothing. “Can you give us a list?” the marketers asked.

“We knew that if we could identify them in their second trimester, there’s a good chance we could capture them for years,” Pole told me. “As soon as we get them buying diapers from us, they’re going to start buying everything else too. If you’re rushing through the store, looking for bottles, and you pass orange juice, you’ll grab a carton. Oh, and there’s that new DVD I want. Soon, you’ll be buying cereal and paper towels from us, and keep coming back.”

The desire to collect information on customers is not new for Target or any other large retailer, of course. For decades, Target has collected vast amounts of data on every person who regularly walks into one of its stores. Whenever possible, Target assigns each shopper a unique code — known internally as the Guest ID number — that keeps tabs on everything they buy. “If you use a credit card or a coupon, or fill out a survey, or mail in a refund, or call the customer help line, or open an e-mail we’ve sent you or visit our Web site, we’ll record it and link it to your Guest ID,” Pole said. “We want to know everything we can.”

Also linked to your Guest ID is demographic information like your age, whether you are married and have kids, which part of town you live in, how long it takes you to drive to the store, your estimated salary, whether you’ve moved recently, what credit cards you carry in your wallet and what Web sites you visit. Target can buy data about your ethnicity, job history, the magazines you read, if you’ve ever declared bankruptcy or got divorced, the year you bought (or lost) your house, where you went to college, what kinds of topics you talk about online, whether you prefer certain brands of coffee, paper towels, cereal or applesauce, your political leanings, reading habits, charitable giving and the number of cars you own. (In a statement, Target declined to identify what demographic information it collects or purchases.) All that information is meaningless, however, without someone to analyze and make sense of it. That’s where Andrew Pole and the dozens of other members of Target’s Guest Marketing Analytics department come in.

Almost every major retailer, from grocery chains to investment banks to the U.S. Postal Service, has a “predictive analytics” department devoted to understanding not just consumers’ shopping habits but also their personal habits, so as to more efficiently market to them. “But Target has always been one of the smartest at this,” says Eric Siegel, a consultant and the chairman of a conference called Predictive Analytics World. “We’re living through a golden age of behavioral research. It’s amazing how much we can figure out about how people think now.”

The reason Target can snoop on our shopping habits is that, over the past two decades, the science of habit formation has become a major field of research in neurology and psychology departments at hundreds of major medical centers and universities, as well as inside extremely well financed corporate labs. “It’s like an arms race to hire statisticians nowadays,” said Andreas Weigend, the former chief scientist at Amazon.com. “Mathematicians are suddenly sexy.” As the ability to analyze data has grown more and more fine-grained, the push to understand how daily habits influence our decisions has become one of the most exciting topics in clinical research, even though most of us are hardly aware those patterns exist. One study from Duke University estimated that habits, rather than conscious decision-making, shape 45 percent of the choices we make every day, and recent discoveries have begun to change everything from the way we think about dieting to how doctors conceive treatments for anxiety, depression and addictions.

This research is also transforming our understanding of how habits function across organizations and societies. A football coach named Tony Dungy propelled one of the worst teams in the N.F.L. to the Super Bowl by focusing on how his players habitually reacted to on-field cues. Before he became Treasury secretary, Paul O’Neill overhauled a stumbling conglomerate, Alcoa, and turned it into a top performer in the Dow Jones by relentlessly attacking one habit — a specific approach to worker safety — which in turn caused a companywide transformation. The Obama campaign has hired a habit specialist as its “chief scientist” to figure out how to trigger new voting patterns among different constituencies.

Researchers have figured out how to stop people from habitually overeating and biting their nails. They can explain why some of us automatically go for a jog every morning and are more productive at work, while others oversleep and procrastinate. There is a calculus, it turns out, for mastering our subconscious urges. For companies like Target, the exhaustive rendering of our conscious and unconscious patterns into data sets and algorithms has revolutionized what they know about us and, therefore, how precisely they can sell.

Inside the brain-and-cognitive-sciences department of the Massachusetts Institute of Technology are what, to the casual observer, look like dollhouse versions of surgical theaters. There are rooms with tiny scalpels, small drills and miniature saws. Even the operating tables are petite, as if prepared for 7-year-old surgeons. Inside those shrunken O.R.’s, neurologists cut into the skulls of anesthetized rats, implanting tiny sensors that record the smallest changes in the activity of their brains.

An M.I.T. neuroscientist named Ann Graybiel told me that she and her colleagues began exploring habits more than a decade ago by putting their wired rats into a T-shaped maze with chocolate at one end. The maze was structured so that each animal was positioned behind a barrier that opened after a loud click. The first time a rat was placed in the maze, it would usually wander slowly up and down the center aisle after the barrier slid away, sniffing in corners and scratching at walls. It appeared to smell the chocolate but couldn’t figure out how to find it. There was no discernible pattern in the rat’s meanderings and no indication it was working hard to find the treat.

The probes in the rats’ heads, however, told a different story. While each animal wandered through the maze, its brain was working furiously. Every time a rat sniffed the air or scratched a wall, the neurosensors inside the animal’s head exploded with activity. As the scientists repeated the experiment, again and again, the rats eventually stopped sniffing corners and making wrong turns and began to zip through the maze with more and more speed. And within their brains, something unexpected occurred: as each rat learned how to complete the maze more quickly, its mental activity decreased. As the path became more and more automatic — as it became a habit — the rats started thinking less and less.

This process, in which the brain converts a sequence of actions into an automatic routine, is called “chunking.” There are dozens, if not hundreds, of behavioral chunks we rely on every day. Some are simple: you automatically put toothpaste on your toothbrush before sticking it in your mouth. Some, like making the kids’ lunch, are a little more complex. Still others are so complicated that it’s remarkable to realize that a habit could have emerged at all.

Take backing your car out of the driveway. When you first learned to drive, that act required a major dose of concentration, and for good reason: it involves peering into the rearview and side mirrors and checking for obstacles, putting your foot on the brake, moving the gearshift into reverse, removing your foot from the brake, estimating the distance between the garage and the street while keeping the wheels aligned, calculating how images in the mirrors translate into actual distances, all while applying differing amounts of pressure to the gas pedal and brake.

Now, you perform that series of actions every time you pull into the street without thinking very much. Your brain has chunked large parts of it. Left to its own devices, the brain will try to make almost any repeated behavior into a habit, because habits allow our minds to conserve effort. But conserving mental energy is tricky, because if our brains power down at the wrong moment, we might fail to notice something important, like a child riding her bike down the sidewalk or a speeding car coming down the street. So we’ve devised a clever system to determine when to let a habit take over. It’s something that happens whenever a chunk of behavior starts or ends — and it helps to explain why habits are so difficult to change once they’re formed, despite our best intentions.

To understand this a little more clearly, consider again the chocolate-seeking rats. What Graybiel and her colleagues found was that, as the ability to navigate the maze became habitual, there were two spikes in the rats’ brain activity — once at the beginning of the maze, when the rat heard the click right before the barrier slid away, and once at the end, when the rat found the chocolate. Those spikes show when the rats’ brains were fully engaged, and the dip in neural activity between the spikes showed when the habit took over. From behind the partition, the rat wasn’t sure what waited on the other side, until it heard the click, which it had come to associate with the maze. Once it heard that sound, it knew to use the “maze habit,” and its brain activity decreased. Then at the end of the routine, when the reward appeared, the brain shook itself awake again and the chocolate signaled to the rat that this particular habit was worth remembering, and the neurological pathway was carved that much deeper.

The process within our brains that creates habits is a three-step loop. First, there is a cue, a trigger that tells your brain to go into automatic mode and which habit to use. Then there is the routine, which can be physical or mental or emotional. Finally, there is a reward, which helps your brain figure out if this particular loop is worth remembering for the future. Over time, this loop — cue, routine, reward; cue, routine, reward — becomes more and more automatic. The cue and reward become neurologically intertwined until a sense of craving emerges. What’s unique about cues and rewards, however, is how subtle they can be. Neurological studies like the ones in Graybiel’s lab have revealed that some cues span just milliseconds. And rewards can range from the obvious (like the sugar rush that a morning doughnut habit provides) to the infinitesimal (like the barely noticeable — but measurable — sense of relief the brain experiences after successfully navigating the driveway). Most cues and rewards, in fact, happen so quickly and are so slight that we are hardly aware of them at all. But our neural systems notice and use them to build automatic behaviors.

Habits aren’t destiny — they can be ignored, changed or replaced. But it’s also true that once the loop is established and a habit emerges, your brain stops fully participating in decision-making. So unless you deliberately fight a habit — unless you find new cues and rewards — the old pattern will unfold automatically.

“We’ve done experiments where we trained rats to run down a maze until it was a habit, and then we extinguished the habit by changing the placement of the reward,” Graybiel told me. “Then one day, we’ll put the reward in the old place and put in the rat and, by golly, the old habit will re-emerge right away. Habits never really disappear.”

Luckily, simply understanding how habits work makes them easier to control. Take, for instance, a series of studies conducted a few years ago at Columbia University and the University of Alberta. Researchers wanted to understand how exercise habits emerge. In one project, 256 members of a health-insurance plan were invited to classes stressing the importance of exercise. Half the participants received an extra lesson on the theories of habit formation (the structure of the habit loop) and were asked to identify cues and rewards that might help them develop exercise routines.

The results were dramatic. Over the next four months, those participants who deliberately identified cues and rewards spent twice as much time exercising as their peers. Other studies have yielded similar results. According to another recent paper, if you want to start running in the morning, it’s essential that you choose a simple cue (like always putting on your sneakers before breakfast or leaving your running clothes next to your bed) and a clear reward (like a midday treat or even the sense of accomplishment that comes from ritually recording your miles in a log book). After a while, your brain will start anticipating that reward — craving the treat or the feeling of accomplishment — and there will be a measurable neurological impulse to lace up your jogging shoes each morning.

Our relationship to e-mail operates on the same principle. When a computer chimes or a smartphone vibrates with a new message, the brain starts anticipating the neurological “pleasure” (even if we don’t recognize it as such) that clicking on the e-mail and reading it provides. That expectation, if unsatisfied, can build until you find yourself moved to distraction by the thought of an e-mail sitting there unread — even if you know, rationally, it’s most likely not important. On the other hand, once you remove the cue by disabling the buzzing of your phone or the chiming of your computer, the craving is never triggered, and you’ll find, over time, that you’re able to work productively for long stretches without checking your in-box.

Some of the most ambitious habit experiments have been conducted by corporate America. To understand why executives are so entranced by this science, consider how one of the world’s largest companies, Procter & Gamble, used habit insights to turn a failing product into one of its biggest sellers. P.& G. is the corporate behemoth behind a whole range of products, from Downy fabric softener to Bounty paper towels to Duracell batteries and dozens of other household brands. In the mid-1990s, P.& G.’s executives began a secret project to create a new product that could eradicate bad smells. P.& G. spent millions developing a colorless, cheap-to-manufacture liquid that could be sprayed on a smoky blouse, stinky couch, old jacket or stained car interior and make it odorless. In order to market the product — Febreze — the company formed a team that included a former Wall Street mathematician named Drake Stimson and habit specialists, whose job was to make sure the television commercials, which they tested in Phoenix, Salt Lake City and Boise, Idaho, accentuated the product’s cues and rewards just right.

The first ad showed a woman complaining about the smoking section of a restaurant. Whenever she eats there, she says, her jacket smells like smoke. A friend tells her that if she uses Febreze, it will eliminate the odor. The cue in the ad is clear: the harsh smell of cigarette smoke. The reward: odor eliminated from clothes. The second ad featured a woman worrying about her dog, Sophie, who always sits on the couch. “Sophie will always smell like Sophie,” she says, but with Febreze, “now my furniture doesn’t have to.” The ads were put in heavy rotation. Then the marketers sat back, anticipating how they would spend their bonuses. A week passed. Then two. A month. Two months. Sales started small and got smaller. Febreze was a dud.

The panicked marketing team canvassed consumers and conducted in-depth interviews to figure out what was going wrong, Stimson recalled. Their first inkling came when they visited a woman’s home outside Phoenix. The house was clean and organized. She was something of a neat freak, the woman explained. But when P.& G.’s scientists walked into her living room, where her nine cats spent most of their time, the scent was so overpowering that one of them gagged.

According to Stimson, who led the Febreze team, a researcher asked the woman, “What do you do about the cat smell?”

“It’s usually not a problem,” she said.

“Do you smell it now?”

“No,” she said. “Isn’t it wonderful? They hardly smell at all!”

A similar scene played out in dozens of other smelly homes. The reason Febreze wasn’t selling, the marketers realized, was that people couldn’t detect most of the bad smells in their lives. If you live with nine cats, you become desensitized to their scents. If you smoke cigarettes, eventually you don’t smell smoke anymore. Even the strongest odors fade with constant exposure. That’s why Febreze was a failure. The product’s cue — the bad smells that were supposed to trigger daily use — was hidden from the people who needed it the most. And Febreze’s reward (an odorless home) was meaningless to someone who couldn’t smell offensive scents in the first place.

P.& G. employed a Harvard Business School professor to analyze Febreze’s ad campaigns. They collected hours of footage of people cleaning their homes and watched tape after tape, looking for clues that might help them connect Febreze to people’s daily habits. When that didn’t reveal anything, they went into the field and conducted more interviews. A breakthrough came when they visited a woman in a suburb near Scottsdale, Ariz., who was in her 40s with four children. Her house was clean, though not compulsively tidy, and didn’t appear to have any odor problems; there were no pets or smokers. To the surprise of everyone, she loved Febreze.

“I use it every day,” she said.

“What smells are you trying to get rid of?” a researcher asked.

“I don’t really use it for specific smells,” the woman said. “I use it for normal cleaning — a couple of sprays when I’m done in a room.”

The researchers followed her around as she tidied the house. In the bedroom, she made her bed, tightened the sheet’s corners, then sprayed the comforter with Febreze. In the living room, she vacuumed, picked up the children’s shoes, straightened the coffee table, then sprayed Febreze on the freshly cleaned carpet.

“It’s nice, you know?” she said. “Spraying feels like a little minicelebration when I’m done with a room.” At the rate she was going, the team estimated, she would empty a bottle of Febreze every two weeks.

When they got back to P.& G.’s headquarters, the researchers watched their videotapes again. Now they knew what to look for and saw their mistake in scene after scene. Cleaning has its own habit loops that already exist. In one video, when a woman walked into a dirty room (cue), she started sweeping and picking up toys (routine), then she examined the room and smiled when she was done (reward). In another, a woman scowled at her unmade bed (cue), proceeded to straighten the blankets and comforter (routine) and then sighed as she ran her hands over the freshly plumped pillows (reward). P.& G. had been trying to create a whole new habit with Febreze, but what they really needed to do was piggyback on habit loops that were already in place. The marketers needed to position Febreze as something that came at the end of the cleaning ritual, the reward, rather than as a whole new cleaning routine.

The company printed new ads showing open windows and gusts of fresh air. More perfume was added to the Febreze formula, so that instead of merely neutralizing odors, the spray had its own distinct scent. Television commercials were filmed of women, having finished their cleaning routine, using Febreze to spritz freshly made beds and just-laundered clothing. Each ad was designed to appeal to the habit loop: when you see a freshly cleaned room (cue), pull out Febreze (routine) and enjoy a smell that says you’ve done a great job (reward). When you finish making a bed (cue), spritz Febreze (routine) and breathe a sweet, contented sigh (reward). Febreze, the ads implied, was a pleasant treat, not a reminder that your home stinks.

And so Febreze, a product originally conceived as a revolutionary way to destroy odors, became an air freshener used once things are already clean. The Febreze revamp occurred in the summer of 1998. Within two months, sales doubled. A year later, the product brought in $230 million. Since then Febreze has spawned dozens of spinoffs — air fresheners, candles and laundry detergents — that now account for sales of more than $1 billion a year. Eventually, P.& G. began mentioning to customers that, in addition to smelling sweet, Febreze can actually kill bad odors. Today it’s one of the top-selling products in the world.

Andrew Pole was hired by Target to use the same kinds of insights into consumers’ habits to expand Target’s sales. His assignment was to analyze all the cue-routine-reward loops among shoppers and help the company figure out how to exploit them. Much of his department’s work was straightforward: find the customers who have children and send them catalogs that feature toys before Christmas. Look for shoppers who habitually purchase swimsuits in April and send them coupons for sunscreen in July and diet books in December. But Pole’s most important assignment was to identify those unique moments in consumers’ lives when their shopping habits become particularly flexible and the right advertisement or coupon would cause them to begin spending in new ways.

In the 1980s, a team of researchers led by a U.C.L.A. professor named Alan Andreasen undertook a study of peoples’ most mundane purchases, like soap, toothpaste, trash bags and toilet paper. They learned that most shoppers paid almost no attention to how they bought these products, that the purchases occurred habitually, without any complex decision-making. Which meant it was hard for marketers, despite their displays and coupons and product promotions, to persuade shoppers to change.

But when some customers were going through a major life event, like graduating from college or getting a new job or moving to a new town, their shopping habits became flexible in ways that were both predictable and potential gold mines for retailers. The study found that when someone marries, he or she is more likely to start buying a new type of coffee. When a couple move into a new house, they’re more apt to purchase a different kind of cereal. When they divorce, there’s an increased chance they’ll start buying different brands of beer.

Consumers going through major life events often don’t notice, or care, that their shopping habits have shifted, but retailers notice, and they care quite a bit. At those unique moments, Andreasen wrote, customers are “vulnerable to intervention by marketers.” In other words, a precisely timed advertisement, sent to a recent divorcee or new homebuyer, can change someone’s shopping patterns for years.

And among life events, none are more important than the arrival of a baby. At that moment, new parents’ habits are more flexible than at almost any other time in their adult lives. If companies can identify pregnant shoppers, they can earn millions.

The only problem is that identifying pregnant customers is harder than it sounds. Target has a baby-shower registry, and Pole started there, observing how shopping habits changed as a woman approached her due date, which women on the registry had willingly disclosed. He ran test after test, analyzing the data, and before long some useful patterns emerged. Lotions, for example. Lots of people buy lotion, but one of Pole’s colleagues noticed that women on the baby registry were buying larger quantities of unscented lotion around the beginning of their second trimester. Another analyst noted that sometime in the first 20 weeks, pregnant women loaded up on supplements like calcium, magnesium and zinc. Many shoppers purchase soap and cotton balls, but when someone suddenly starts buying lots of scent-free soap and extra-big bags of cotton balls, in addition to hand sanitizers and washcloths, it signals they could be getting close to their delivery date.

As Pole’s computers crawled through the data, he was able to identify about 25 products that, when analyzed together, allowed him to assign each shopper a “pregnancy prediction” score. More important, he could also estimate her due date to within a small window, so Target could send coupons timed to very specific stages of her pregnancy.

One Target employee I spoke to provided a hypothetical example. Take a fictional Target shopper named Jenny Ward, who is 23, lives in Atlanta and in March bought cocoa-butter lotion, a purse large enough to double as a diaper bag, zinc and magnesium supplements and a bright blue rug. There’s, say, an 87 percent chance that she’s pregnant and that her delivery date is sometime in late August. What’s more, because of the data attached to her Guest ID number, Target knows how to trigger Jenny’s habits. They know that if she receives a coupon via e-mail, it will most likely cue her to buy online. They know that if she receives an ad in the mail on Friday, she frequently uses it on a weekend trip to the store. And they know that if they reward her with a printed receipt that entitles her to a free cup of Starbucks coffee, she’ll use it when she comes back again.

In the past, that knowledge had limited value. After all, Jenny purchased only cleaning supplies at Target, and there were only so many psychological buttons the company could push. But now that she is pregnant, everything is up for grabs. In addition to triggering Jenny’s habits to buy more cleaning products, they can also start including offers for an array of products, some more obvious than others, that a woman at her stage of pregnancy might need.

Pole applied his program to every regular female shopper in Target’s national database and soon had a list of tens of thousands of women who were most likely pregnant. If they could entice those women or their husbands to visit Target and buy baby-related products, the company’s cue-routine-reward calculators could kick in and start pushing them to buy groceries, bathing suits, toys and clothing, as well. When Pole shared his list with the marketers, he said, they were ecstatic. Soon, Pole was getting invited to meetings above his paygrade. Eventually his paygrade went up.

At which point someone asked an important question: How are women going to react when they figure out how much Target knows?

“If we send someone a catalog and say, ‘Congratulations on your first child!’ and they’ve never told us they’re pregnant, that’s going to make some people uncomfortable,” Pole told me. “We are very conservative about compliance with all privacy laws. But even if you’re following the law, you can do things where people get queasy.”

About a year after Pole created his pregnancy-prediction model, a man walked into a Target outside Minneapolis and demanded to see the manager. He was clutching coupons that had been sent to his daughter, and he was angry, according to an employee who participated in the conversation.

“My daughter got this in the mail!” he said. “She’s still in high school, and you’re sending her coupons for baby clothes and cribs? Are you trying to encourage her to get pregnant?”

The manager didn’t have any idea what the man was talking about. He looked at the mailer. Sure enough, it was addressed to the man’s daughter and contained advertisements for maternity clothing, nursery furniture and pictures of smiling infants. The manager apologized and then called a few days later to apologize again.

On the phone, though, the father was somewhat abashed. “I had a talk with my daughter,” he said. “It turns out there’s been some activities in my house I haven’t been completely aware of. She’s due in August. I owe you an apology.”

When I approached Target to discuss Pole’s work, its representatives declined to speak with me. “Our mission is to make Target the preferred shopping destination for our guests by delivering outstanding value, continuous innovation and exceptional guest experience,” the company wrote in a statement. “We’ve developed a number of research tools that allow us to gain insights into trends and preferences within different demographic segments of our guest population.” When I sent Target a complete summary of my reporting, the reply was more terse: “Almost all of your statements contain inaccurate information and publishing them would be misleading to the public. We do not intend to address each statement point by point.” The company declined to identify what was inaccurate. They did add, however, that Target “is in compliance with all federal and state laws, including those related to protected health information.”

When I offered to fly to Target’s headquarters to discuss its concerns, a spokeswoman e-mailed that no one would meet me. When I flew out anyway, I was told I was on a list of prohibited visitors. “I’ve been instructed not to give you access and to ask you to leave,” said a very nice security guard named Alex.

Using data to predict a woman’s pregnancy, Target realized soon after Pole perfected his model, could be a public-relations disaster. So the question became: how could they get their advertisements into expectant mothers’ hands without making it appear they were spying on them? How do you take advantage of someone’s habits without letting them know you’re studying their lives?

Before I met Andrew Pole, before I even decided to write a book about the science of habit formation, I had another goal: I wanted to lose weight.

I had got into a bad habit of going to the cafeteria every afternoon and eating a chocolate-chip cookie, which contributed to my gaining a few pounds. Eight, to be precise. I put a Post-it note on my computer reading “NO MORE COOKIES.” But every afternoon, I managed to ignore that note, wander to the cafeteria, buy a cookie and eat it while chatting with colleagues. Tomorrow, I always promised myself, I’ll muster the willpower to resist.

Tomorrow, I ate another cookie.

When I started interviewing experts in habit formation, I concluded each interview by asking what I should do. The first step, they said, was to figure out my habit loop. The routine was simple: every afternoon, I walked to the cafeteria, bought a cookie and ate it while chatting with friends.

Next came some less obvious questions: What was the cue? Hunger? Boredom? Low blood sugar? And what was the reward? The taste of the cookie itself? The temporary distraction from my work? The chance to socialize with colleagues?

Rewards are powerful because they satisfy cravings, but we’re often not conscious of the urges driving our habits in the first place. So one day, when I felt a cookie impulse, I went outside and took a walk instead. The next day, I went to the cafeteria and bought a coffee. The next, I bought an apple and ate it while chatting with friends. You get the idea. I wanted to test different theories regarding what reward I was really craving. Was it hunger? (In which case the apple should have worked.) Was it the desire for a quick burst of energy? (If so, the coffee should suffice.) Or, as turned out to be the answer, was it that after several hours spent focused on work, I wanted to socialize, to make sure I was up to speed on office gossip, and the cookie was just a convenient excuse? When I walked to a colleague’s desk and chatted for a few minutes, it turned out, my cookie urge was gone.

All that was left was identifying the cue.

Deciphering cues is hard, however. Our lives often contain too much information to figure out what is triggering a particular behavior. Do you eat breakfast at a certain time because you’re hungry? Or because the morning news is on? Or because your kids have started eating? Experiments have shown that most cues fit into one of five categories: location, time, emotional state, other people or the immediately preceding action. So to figure out the cue for my cookie habit, I wrote down five things the moment the urge hit:

Where are you? (Sitting at my desk.)

What time is it? (3:36 p.m.)

What’s your emotional state? (Bored.)

Who else is around? (No one.)

What action preceded the urge? (Answered an e-mail.)

The next day I did the same thing. And the next. Pretty soon, the cue was clear: I always felt an urge to snack around 3:30.

Once I figured out all the parts of the loop, it seemed fairly easy to change my habit. But the psychologists and neuroscientists warned me that, for my new behavior to stick, I needed to abide by the same principle that guided Procter & Gamble in selling Febreze: To shift the routine — to socialize, rather than eat a cookie — I needed to piggyback on an existing habit. So now, every day around 3:30, I stand up, look around the newsroom for someone to talk to, spend 10 minutes gossiping, then go back to my desk. The cue and reward have stayed the same. Only the routine has shifted. It doesn’t feel like a decision, any more than the M.I.T. rats made a decision to run through the maze. It’s now a habit. I’ve lost 21 pounds since then (12 of them from changing my cookie ritual).

Posted via email from Tony Burkhart